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What are the indications of Xanax?
Management of anxiety disorders or the short-term relief of the symptoms of anxiety and panic disorders with or without agoraphobia are Xanax indications. Anxiety orientation associated with the stress of everyday life usually does not require treatment with an amniolytic. Anxiety, can be depressed, is also responsive to Xanax. The effectiveness of Xanax for long-term use, for example, >4 months has not been established by systematic clinical trials. The physician should periodically re-assess the usefulness of Xanax for the individual patient.
Pharmacokinetics
Following oral administration of alprazolam immediate-release tablet, alprazolam is readily absorbed. Peak concentration in the plasma occurs in 1 - 2 hours following administration. Plasma levels are proportional to the dose given over the dose range of 0.5 - 3 mg. Peak levels of a 8 - 37 mg/mL were observed. The mean plasma elimination half-life of alprazolam has been found to be about 11.2 hours (range: 6.3 – 26.9 hours) in healthy adults using a specific assay methodology.
The mean absolute bioavailability of alprazolam from alprazolam extended-release tablets is approximately 90% and the relative bioavailability compared to alprazolam immediate-release tablets is 100%. The bioavailability and pharmacokinetics of alprazolam following administration of alprazolam extended-release tablets are similar to that for alprazolam immediate-release tablets, with the exemption of a lower rate of absorption. The slower absorption rate results in a relatively constant concentration that is maintained between 5 – 11 hours after the dosing. The pharmacokinetics of alprazolam and its two major active metabolytes (4-hydroxyalprazolam and alpha-hydroxyalprazolam are linear and concentrations are proportional up to the recommended . Contraindications
Patient with known sensitivity to Xanax or other benzodiazepines.
Warnings
Xanax is not of value in the treatment of psychotic patients and should not be employed in lieu of appropriate treatment for psychosis
